Imidacloprid binds to the acetylcholine receptor on the postsynaptic part of the nerve cells of the flea; this will cause paralysis and death of the flea. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. During the first 30 minutes after application, monitor to ensure that your dog does not lick the product. WARNINGS: DO NOT ADMINISTER THIS PRODUCT ORALLY. Dogs under 25kg Apply between the shoulder blades. Choosing Treatment for Dogs With Generalised Demodicosis – Isoxazolines or Imidacloprid and Moxidectin? Approved for use in cats over 9 weeks of age. General Description: Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. Cautions. In cats, moxidectin is dosed at 10 mg/kg imidacloprid with 1 mg/kg moxidectin (Advantage® Multi) applied topically every 30 days. (imidacloprid + moxidectin) Topical Solution. Do not bathe your pet for at least 4 days after its application. Moxidectin is safe for dogs in the correct dosage, but it can have significant side-effects. In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months. Using both an insecticide (imidacloprid) and a parasiticide (moxidectin) together, Advantage Multi for Dogs is a 100% effective, monthly, topical solution for heartworm control, as well as for fleas, mites, and other intestinal parasites. They’re potentially deadly for your dog. Advantage Multi (imidacloprid moxidectin) – Heartworm Frontline Plus Flea & Tick Treatment for Cats, 3 Month Petco Prescribing Information for Veterinary Professionals Advantage Multi (imidacloprid moxidectin) provides broad-spectrum parasite protection in a convenient monthly topical application, potentially increasing compliance for dogs and cats that may not prefer oral medications. Moxidectin is also effective against ear mites, notoedric mange in cats and sarcoptic mange in dogs. Three studies were conducted to evaluate higher oral moxidectin doses for efficacy against confirmed ML-resistant D. immitis strains. Moxidectin is available in 30-, 68-, and 136-mcg tablets for dogs; 20-mg/mL equine oral gel; 5-mg/mL cattle pour-on; 1-mg/mL oral drench for sheep; 10-mg/mL injectable solution for cattle; and Quest 2% gel for horses (20 mg/mL). Efficacy in dogs treated topically with the imidacloprid and moxidectin combination, was 9.8% at Day 28, 45.4% at Day 56 and 0% at Day 84, and was significantly (P < 0.01) lower than the fluralaner treated group at each post-treatment time point. Advocate, a patented combination of Imidacloprid (from Advantage) and Moxidectin, is a break-through in the treatment of parasites in dogs. The study was undertaken to evaluate and compare the efficacy of an imidacloprid (10% w/v)/moxidectin (2.5% w/v) combination (Advocate Bayer HealthCare, Animal Health) with that of selamectin for the treatment of Sarcoptes scabiei on dogs. The active ingredients in Advantage Multi for Dogs are Imidacloprid and Moxidectin. Remove any collar prior to application and replace when product is dry. Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and multiple oral dosages. Fourteen dogs were treated with a topical formulation containing 10% w/v imidacloprid and 2.5% w/v moxidectin (Advocate®, Advantage Multi®, Bayer), monthly for nine months, associated to doxycycline (10 mg/kg/BID) for the first 30 days. Parasitol Res 90 Suppl 3, S142-143 PubMed. Imidacloprid, the medication paired with topical moxidectin, begins to kill fleas within 4 hours. How is moxidectin given? Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. Advantage Multi for Dogs Advantage Multi has become a staple in the world of flea prevention, and for good reason. Symptoms of Imidacloprid Toxicity in Dogs. 17. ADVOCATE for DOGS and CATS - SPOT-ON against FLEAS, MITES, HEARTWORMS and ROUNDWORMS - BAYER - imidacloprid + moxidectin - neonicotinoid + macrocyclic lactone Brand: ADVOCATE ® Company: BAYER. Advantage Multi® has late-dose forgiveness, so your dog’s heart is protected even when you’re a few days late*. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. Advocate treats and protects against the major parasit Advocate treats and protects against the major parasit Advantage Multi for Dogs is not for human use, and should always be kept out of the reach of children. Advocate, a patented combination of Imidacloprid (from Advantage) and Moxidectin, is a break-through in the treatment of parasites in dogs. Heartworms are not just gross. This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. High doses that are able to cross the blood-brain barrier have a neurotoxic effect and untreated moxidectin poisoning can result in severe symptoms or death. Advocate treats and protects against the major parasites of your pet, inside and out. Thirty naturally infested dogs, of which one was later withdrawn because of distemper, were allocated to two equal groups and individually housed. Exposure can take place through ingestion or topical exposure. It will also treat and control whipworms in dogs and ear mites in cats. Three dogs were presented with a history of oral administration of a topical endectocide containing imidacloprid and moxidectin. If a dose of the topical product is skipped, it is important to use it as soon as this is discovered to avoid loss of heartworm protection. Topically applied test articles were administered once on test day 0 as follows: 10% imidacloprid+2.5% moxidectin (52 dogs); 2.5% moxidectin mono solution (eight dogs); 10% imidacloprid mono solution (16 dogs); and placebo solution (12 dogs). In 2003, it was shown that when eight dogs were administered 10% imidacloprid + 2.5% moxidectin topical solution and subsequently infected with 300 Uncinaria stenocephala 18 days later, neither immature nor mature adult hookworms were present 21 days after infection, while the eight nontreated dogs harbored a mean of 4.6 (SD ± 3.9) immature adults and 8.1 (SD ± 4.3) mature adults . Toxic Dose Advantage Multi® for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. In dogs, oral moxidectin is dosed at 1.5 mcg per pound (3 mcg/kg) once monthly in dogs. Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. Six dogs were treated with melarsomine (Immiticide®, Merial) (2.5 mg/kg) at enrollment, followed one month later by two injections 24 h apart. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Advocate (imidacloprid / moxidectin) EMA/479129/2010 Page 2/3 . Avoid any type of skin contact with the application site for 30 minutes following treatment with this topical flea medication. Part the hair until the skin is visible. Parasitic infections are common and include external parasites (fleas, ticks, mites) and internal parasites (intestinal worms, lungworms, heartworms). FORMULATION: «spot-on» solution for topical administration on the back of the animals (also called pipettes, squeeze-ons, drop-ons, etc.) Do not apply this medication to irritated skin. Wash hands thoroughly with soap and water after handling. They were diagnosed with imidacloprid and moxidectin intoxication, having ingested doses ranging from 7.5 to 1.4 mg/kg of imidacloprid and 1.9 to 2.8 mg/kg of moxidectin. 6 The animal should be standing for easy application. Injectable moxidectin is not approved for use in heartworm infected dogs. Quest Plus gel for horses contains 20 mg/mL (2%) plus 125 mg praziquantel (12.5%). Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. It contains two active substances, imidacloprid and moxidectin. Topical formulations of imidacloprid in combination with moxidectin are used on dogs and cats to prevent heartworms as well as control fleas, ear mites, and intestinal nematodes. Imidacloprid is used in combination with permethrin in dog-only spot-on products that control fleas and ticks. Moxidectin is applied topically to the skin. For dogs, imidacloprid is sold under the brand name of Advantage and is used as a topical flea control once monthly. Hellmann K, Knoppe T, Radeloff I, Heine J (2003) The anthelmintic efficacy and the safety of a combination of imidacloprid and moxidectin spot-on in cats and dogs under field conditions in Europe. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Dogs over 25kg Apply by dividing the dose between the shoulder blades, on the midline of the back between the hips, and at one point in between. Dogs were blocked according to gender and body weight on test day -1. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Assurity Plus Spot On for Dogs provides broad-spectrum parasite protection in a convenient monthly application: ... (Imidacloprid & Moxidectin) Assurity Plus Spot On offers protection against multiple parasites in one easy to administer topical monthly dose – no need to battle with tablets! Company: Bayer Animal Health for dogs. Efficacy and safety of treatment with imidacloprid 10%+moxidectin 2.5% spot-on (Advocate, Advantage multi; Bayer AG, Leverkusen, Germany) were tested in dogs naturally infested with Sarcoptes scabiei or Otodectes cynotis in a multi-centre, controlled, randomized, blinded field study conducted in France, Germany, Albania and the UK. How is Advocate used? 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